Identical twins Antipholus of Ephesus and Antipholus of Syracuse, were separated from each other in a shipwreck as young children. Their servants, both named Dromio, are also long-separated identical twins. When the pair from Syracuse come to Ephesus, a comedy of errors and mistaken identities ensues when the wives of the Ephesians, Adriana and her servant Luce, mistake the two strangers for their husbands. Adriana's sister Luciana and the Syracuse Antipholus fall in love. But all ends happily.