When ambition goes unchecked and the person seeks to achieve the goal using any means possible, it is usually to guarantee absolute success and security.
Corrupting power
Killing of King Duncan, MacDuff's family etc.
Course without forethought
Morals and consequences are not taken into consideration or thought of
"Glamis thou art, and Cawdor; and shalt be
What thou art promised" IV 13,14.
"Hie thee hither,
That I may pour my spirits in thine ear;
And chastise with the valar of my tongue
All that impedes thee from the golden round." IV 23-26
"Great Glaims!
Worthy Cawdor!
Greater than both, but the all-hail hereather" IV 52,53