Andrei was born to Dmitry and Ekaterina Sakharov. His father taught physics and wrote popular scientific works and textbooks. His mother was a house wife.
Andrei was married two times. His first wife, Klavdia Vikhireva, who he had three children with, died in 1969. In 1971 he married his second wife, Yelena Bonner. They were married until his death in 1989.
Andrei was known for his ground-breaking research in Controlled Thermonuclear Fusion. That research led to the development of the Soviet's first hydrogen bomb.