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Cannabis Hyperemesis

Published on Dec 10, 2018

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PRESENTATION OUTLINE

Hurling While High

Ian Mitchell, MD, FRCP

Untitled Slide

  • Emergency Physician RIH
  • Clinical Associate Professor, Dept of EM
  • Site Scholar, Kamloops Family Medicine Residency Program

Cannabis

  • QI for RCT of cannabis for PTSD- UBCO
  • Provider- MCRCI
  • Editor/Contributor - Using Medical Cannabis/Tilray
  • Senate Report on Cannabis

Disclosures

  • Speaking fees: Tilray, Maricann
  • Consulting: Tilray, Shoppers Drug Mart, MD Briefcase
  • Investments: SDM
Photo by Rick Proctor

Allen,2004, Adelaide

 ?Moore, 1996, Sydney

CHS patients

  • male
  • prolonged cannabis use
  • abdominal pain
  • scromiting
  • hot showers/baths give relief
Photo by Mike Burns

Untitled Slide

  • Investigations negative
  • $25 000/year costs
  • Cessation only cure
  • Challenge causes return of symptoms
Photo by Steve E.

CHS vs CVS

  • CVS more in women
  • Heat cure rare in CVS
  • CVS begins in childhood
  • mitochondrial DNA ?

Etiology

  • THC decreases temperature
  • Cannabinoid receptors in hippocampus and gut
Photo by svennevenn

TRPV

  • pain (capsaicin)
  • triggered by high temperatures
Photo by naotoj

Jamaica

Photo by PoshMoggy

Neem Oil Hypothesis

  • unapproved pesticide
  • toxicity leads to vomiting
  • no CHS from edibles
  • sporadic distribution of CHS
Photo by sk_vel

Neem Oil Hypothesis

  • toxicity doesn't include hot showers
  • CHS seen with synthetic cannabinoids
Photo by { pranav }

Treatment

  • Rehydration
  • Antiemetics
  • Benzodiazepines

Haloperidol 5 mg im/iv

Olanzapine 5 mg iv
Olanzapine has less EPS and less cardiac side effects than haloperidol, but is more expensive.

Capsaicin

0.075% to abdomen / back of arms

How Long?

4-10 days ?
Photo by nisuspi

Recidivism

?Benzodiazepines for withdrawal
Photo by Dan4th

Legalization

Doubling of cases in Colorado

Stigma

LWBS 20%
Photo by nikoretro

CHS:Public Health Implications and a Novel Treatment Guideline, LaPoint, et al, 2017, West J E M

Questions?

Photo by sobriquet.net