MECHANISM OF ACTION Serotonin antagonist and reuptake inhibitors (SARIs) are a class of drugs used mainly as antidepressants, but also as anxiolytics and hypnotics. They act by antagonizing serotonin receptors such as 5-HT2A and inhibiting the reuptake of serotonin, norepinephrine, and/or dopamine.
Many disappear within 4 weeks (adaption phase) •Side effects more manageable compared to MAOIs and TCAs •Sexual side effects are common •SSRI cessation syndrome •Brain zaps •Sexual dysfunction
PRECAUTIONS/ CONTRAINDICATIONS Clinical Worsening And Suicide Risk. ... Serotonin Syndrome. ... Angle Closure Glaucoma. ... Screening Patients For Bipolar Disorder And Monitoring For Mania/Hypomania. ... QT Prolongation And Risk Of Sudden Death. ... Use In Patients With Heart Disease. ... Orthostatic Hypotension And Syncope. ... Abnormal Bleeding.