DoWN Syndrome

• Kelly Smith
• Med1010
• Florida Technical college
• Dr.Garrastegui
• 10/16/2013

DOWN SYNDROME

• Is the most common chromosomal disorder
• Occurs when a person has a full or partial extra copy of
• of chromosome 21.

errors in cell division that cause Down syndrome

• disjunction:developing egg or sperm divides incorrectly
• 95% of cases are caused by disjunction
• translocation:happens before fertilization 4%
• mosaicism:occurs after cell division. About 1%

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Signs and Symptoms

• Common physical traits:
• Small stature,upward slant to the eyes,hypotonia,
• Flat hypoplastic face,transverse palmers crease,protruding
• Tounge.mental retardation can range in severity.
• Some may have a few traits and others may have none.

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TREATMENT

• There is no cure for Down syndrome or specific
• Treatment
• There are only treatments for the conditions and
• defects caused by Down syndrome .

• Even though many individuals with Down syndrome
• Have mental and physical limitations they can live
• a productive and healthy life.

REFERENCES

• http://www.cdc.gov/ncbddd/features/DownSyndromeWorldDay-2012.html
• Patterson, D. The integrated map of human chromosome 21. In Etiology and Pathogenesis of Down Syndrome, Wiley-Liss, 1995, p 43-55.
• Hernandez D and Fisher EMC. Down syndrome genetics: unravelling a multifactorial disorder. Hum. mol. Genet., 5: 1411-1416, 1996.
• Coleman, Mary and Rogers, PT. Medical Care in Down Syndrome: A Preventative Medicine Approach. Marcel Dekker, Inc, NY, 1992.
• Shapiro, BL. Whither Down syndrome critical regions? Hum Genet 99: 421-423, 1997