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Dr As A Teacher 9-4-15

Published on Nov 18, 2015

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PRESENTATION OUTLINE

1.

RHEUMATOLOGY

Photo by AJC ajcann.wordpress.com
2.

SLE

  • Constitutional symptoms
  • Photosensitivity, malar rash, discoid LE
  • Non deforming poly arthritis/polyarthralgia
  • Pulmonary, cardiac, haematological etc.
  • ANA present but very non-specific
3.

ANTI DOUBLE STRANDED DNA

VERY SPECIFIC FOR SLE
4.

ANTI-ENA

  • Anti-Ro: maternal anti-Ro associated with neonatal lupus
  • Anti-La
  • Anti-Smith antibodies also very specific
5.

C3/C4 LEVELS

CORRELATE NEGATIVELY- DECREASED LEVELS = INCREASED DISEASE ACTIVITY
6.

SJOGREN'S SYNDROME

DRY EYES, DRY MOUTH, FATIGUE, ARTHRALGIA
7.

ANTI-RO +/- ANTI- LA

ANTI-RO AND/OR ANTI-LA
8.

SYSTEMIC SCLEROSIS

VASCULOPATHY, RAYNAUDS, FIBROSIS
9.

LIMITITED/CREST TYPE

ANTI-CENTROMERE ANTIBODIES
10.

DIFFUSE TYPE

ANTI-SCL-70 ANTIBODIES
11.

MIXED CTD

MYOSITIS, RAYNAUDS, SCLERODACTYLY, ALOPECIA ETC
12.

ANTI-RNP ANTIBODY

13.

POLYMYOSITIS

MUSCLE WEAKNESS, INSIDIOUS ONSET, MYALGIA, SYMMETRICAL PROXIMAL MUSCLES
14.

DERMATOMYOSITIS

SIMILAR: CUTANEOUS FEATURES I.E. GOTTRONS, SHAWL, HELIOTROPE RASH
15.

ANTI-JO-1

ANA POSITIVE BUT NOT SPECIFIC
16.

ANTI-PHOSPHOLIPID SYNDROME

THROMBOSIS; PREGANCY LOSS/RECURRENT MISCARRIAGE
17.

ANTI-CARDIOLIPIN ANTIBODIES

18.

RHEUMATOID ARTHRITIS

  • Anti CCP antibodies are relatively specific
  • RF not specific; better as a prognostic factor
19.

QUIZ TIME!!

Photo by Mancha Extraña

Alison Thompson