Protein folding is the process by which a protein structure assumes its functional.

It is the physical process by which a polypeptide folds into its characteristic.

functional three-dimensional structure from random coil.

The correct three-dimensional structure is essential to function.

Each protein exists as an unfolded polypeptide or random coil.

The amino-acid sequence of a protein determines its native conformation.

A protein molecule folds spontaneously during or after biosynthesis.

Folded proteins usually have a side chain.

Packing stabilizes the folded state, and charged or side chains occupy.

the solvent-exposed surface where they interact with surrounding water.