Folding Proteins
Published on Dec 19, 2015
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PRESENTATION OUTLINE
IS THE PROCESS BY WHICH A PROTEIN STRUCTURE ASSUMES ITS FUNCTIONAL SHAPE OR CONFORMATION
Photo by Argonne National Laboratory
IT IS THE PHYSICAL PROCESS BY WHICH A POLYPEPTIDE FOLDS INTO ITS CHARACTERISTIC AND FUNCTIONAL THREE-DIMENSIONAL STRUCTURE FROM RANDOM COI
Photo by Darwin Bell
EACH PROTEIN EXISTS AS AN UNFOLDED POLYPEPTIDE OR RANDOM COIL WHEN TRANSLATED FROM A SEQUENCE OF MRNA TO A LINEAR CHAIN OF AMINO ACIDS
Photo by Stuck in Customs
THIS POLYPEPTIDE LACKS ANY DEVELOPED THREE-DIMENSIONAL STRUCTURE (THE LEFT HAND SIDE OF THE NEIGHBORING FIGURE).
Photo by blmiers2
AMINO ACIDS INTERACT WITH EACH OTHER TO PRODUCE A WELL-DEFINED THREE-DIMENSIONAL STRUCTURE, THE FOLDED PROTEIN (THE RIGHT HAND SIDE OF THE FIGURE), KNOWN AS THE NATIVE STATE. THE RESULTING THREE-DIMENSIONAL STRUCTURE IS DETERMINED BY THE AMINO ACID SEQUENCE (ANFINSEN'S DOGMA).[2]
Photo by Lon&Queta
THE CORRECT THREE-DIMENSIONAL STRUCTURE IS ESSENTIAL TO FUNCTION, ALTHOUGH SOME PARTS OF FUNCTIONAL PROTEINS MAY REMAIN UNFOLDED.[3] FAILURE TO FOLD INTO NATIVE STRUCTURE PRODUCES INACTIVE PROTEINS THAT ARE USUALLY TOXIC
Photo by ecstaticist
SEVERAL NEURODEGENERATIVE AND OTHER DISEASES ARE BELIEVED TO RESULT FROM THE ACCUMULATION OF AMYLOID FIBRILS FORMED BY MISFOLDED PROTEINS
Photo by Fishking_1
MANY ALLERGIES ARE CAUSED BY THE FOLDING OF THE PROTEINS, FOR THE IMMUNE SYSTEM DOES NOT PRODUCE ANTIBODIES FOR CERTAIN PROTEIN STRUCTURES.[5]
Photo by archer10 (Dennis)
