HETEROCHROMIA

PHENOTYPICAL DISCRIPTION

• Abnormal color in one or both eyes
• Sectoral is on one section of the eye
• Central is abnormal color around the pupil
• Full heterochromia is one eye is a complete different color

CAUSES OF HETEROCHROMIA

• Bleeding hemorrhage
• Waardenburg syndrome
• Neurofibromatosis or tumor
• Glaucoma and some medicines used to treat
• Physical injury and Inflammation affecting the eye

CONGENITAL HETEROCHROMIA

• Heterochromia that is congenital is inherited as an autosomal dominant trait.
• Heterochromia is passed from mom or dad and or both

HETEROCHROMIA IN ANIMALS

• Heterochromia appears in animals due to inbreeding
• Cats, dogs, wolves
• Big cats, monkeys
• Horses and owls
• And many others can have heterchromia

LOCATION OF HETEROCHROMIA

• EYCL3, chromosome 15, codes brown/blue eye color (BEY)
• EYCL1, chromosome 19, codes green/blue eye color (GEY)
• PAX3 gene, Waardenburg syndrome

HOW MANY PEOPLE HAVE IT

• 11 people per 1000 people have it in America
• Simon Pegg, Mila Kulis, Keifer Sutherland, Dan Akroyd
• Christopher Walken, Josh Henderson, Jayne Seymour
• Kate Bosworth dancer Michael Flatley
• dancer Michael Flatley

TREATMENT OR CURE

• Contacts
• Laser eye surgery

ENVIRONMENTAL LINK

• Bleeding hemorrhage
• some medicines used to treat glaucoma
• Physical injury and Inflammation affecting the eye

WORKS CITED

• http://en.wikipedia.org/wiki/Heterochromia
• http://www.scientificamerican.com/article.cfm?id=how-does-someone-get-two
• http://www.bios.niu.edu/johns/humgen/diff_eye.htm
• http://www.visioneyeinstitute.com.au/heterochromia/
• Gilbert, Patricia. Dictionary of syndromes and inherited disorders. 3rd ed. Chicago: Fitzroy Dearborn Publishers, 2000

WORKS CITED

• Kelly, Evelyn B. Encyclopedia of Human Genetics and Disease. Vol. 1. Santa Barbera, CA : Greenwood, 2013.
• Clayman, Charles B.,ed. The American Medical Association Encyclopedia of Medicine. New York: Random House, 1989.