HEMOPHILIA

CAUSE

• Genetic
• May be acquired (antibodies attack clotting factors)
• Mainly male (disease only found in X chromosomes)
• 1 in 5000 males with disorder
• Can damage organs and tissues

SYMPTOMS

• Internal bleeding in joints without serious injury
• Bleeding in brain

BLEEDING IN JOINT SYMPTOMS

• Tightness in joint without visual signs
• Swollen
• Hot
• Painful to bend

BLEEDING IN BRAIN SYMPTOMS

• Long lasting headaches
• Repeated vomiting
• Clumsiness of limbs
• Sleepiness and changes in behavior
• Seizures

SEVERITY

• Mild: 5-40% normal clotting factor
• Moderate: 1-5%
• Severe: less than 1%

TREATMENT

• Replacement therapy
• Concentrates of VIII or IX dripped into vein
• Made from human blood or recombinant
• Treated on regular basis or when bleeding occurs

PROBLEMS WITH TREATMENT

• Develops antibodies that attack clotting factors
• Develops viral infections
• Damages joints or muscles

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