Consistency of colour, font, theme, proper use of white space.
Avoid the powerpoint template themes – they add extra clutter and take up the valuable real estate space of your slide.
A white background works better than a dark background in smaller lecture rooms.
Otherwise a dark (black background) with white text for larger rooms.
Align the elements on your slide to create meaning, relationships and focal points.
See the principles presented by Garr Reynolds:
http://www.presentationzen.com/