Anne of Green Gables was denied publishing every time until 1908.
Anne of Green Gables, her most famous novel, was denied publishing until 1908. When she wrote the original in 1905, not a single publishing company accepted it. Then she gave up, put it in a hatbox and forgot about it until 1907, where she tried to publish it again. Eventually it was accepted by the Boston page company in Massachusettes in 1908.