OSTEOSARCOMA

INTRO

• Osteosarcoma is cancer of the bone
• Osteosarcoma can develop in any bone
• It develops most commonly in the proximal tibia and distal femur
• Arises most commonly from the wider part of the bone called metaphysis
• It is the most common bone cancer found in children and adolescents

800 NEW CASES IN U.S

SYMPTOMS

• Pain, swelling, and decreased joint motion
• Tenderness and redness where the tumor is
• Limited movement
• Limping, if it's in the leg
• Pain lifting if it's the arms

Untitled Slide

DIAGNOSIS

• Blood tests
• X-rays
• Radionuclide Bone Scan
• Magnetic resonance imaging (MRI)
• Computerized Tomography Scan (CT Scan)

Untitled Slide

TREATMENT

• Osteosarcoma is treated with surgery and chemotherapy
• In years past they would amputate the extremity where the
• Tumor was found.
• Surgical removal of gross and microscopic tumor
• Is required to prevent reoccurrence

Untitled Slide

POSSIBLE CAUSES

• Genetic changes can cause immature bone cells
• To become tumor cells instead of healthy bones
• Rb gene is a suppressor cell that controls growth of cells
• When mutated it no longer controls cell growth and tumor can form

PREVENTION

• There are no preventions
• No immunities either

HISTORY

• The history of osteosarcoma is sketchy
• No one knows for certain when it started
• 1932-One of the oldest case was found in a
• Prehistoric relative of man

SOURCES

• http://kidshealth.org/parent/medical/cancer/cancer_osteosarcoma.html
• http://www.stjude.org/stjude/v/index.jsp?vgnextoid=e6ab061585f70110VgnVCM10...
• http://www.cancer.org/acs/groups/cid/documents/webcontent/003129-pdf.pdf
• http://www.cancer.net/cancer-types/osteosarcoma-childhood/risk-factors
• http://www.nytimes.com/health/guides/disease/osteosarcoma/