Alzheimerâs Disease by Alyssa Landrum

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Alzheimerâs Disease

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PRESENTATION OUTLINE

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BIOPROSPECTING

What's Up With Alzheimer's

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Organisms Affected

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The abnormalities of Alzheimer's disease can be found in primates, ie humans, apes and monkeys, and in certain strains of mice.

How organisms affected by Alzheimer's survive in their environment

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Many of the organisms affected by Alzheimer’s disease cannot live independently. The disease causes the organism to forget nearly everything it knows including names of loved ones, times for medicine, or how to take care of themselves.

The First Discovery

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Alzheimer's disease is named after Dr. Alois Alzheimer. In 1906, Dr. Alzheimer noticed changes in the brain tissue of a woman who had died of an unusual mental illness. Her symptoms included memory loss, language problems, and unpredictable behavior.

BIOCHEMISTRY

THE CHEMISTRY YOU WON’T FALL IN LOVE WITH

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The biochemistry of Alzheimer's disease (AD), one of the most common causes of adult dementia, is not yet very well understood. AD has been identified as a protein misfolding disease due to the accumulation of abnormally folded amyloid beta protein in the brains of Alzheimer's patients.

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HYDROPHOBIC?/HYDROPHILIC?

Substitutions of hydrophobic amino acids reduce the amyloidogenicity of Alzheimer's disease beta A4 peptides.
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the deposit of fibrillar proteins within the brain as amyloid plaques, causing an atrophy of grey matter composed of dead neurons and synapses. Several genetic precursors have been implicated in AD-related amyloid formation.

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THE NEGATIVE “TUDE” OF ALZHEIMER’S

The molecular structure of one of the proteins in the fine fibers of the brain plaques that are a hallmark of Alzheimer's disease, researchers have found. This molecule, called amyloid beta-42, is toxic to nerve cells and is believed to provoke the disease cascade

13.

THE GOOD GUY AMINO ACIDS

The other major histological hallmark of AD brain in addition to amyloid plaques is the neurofibrillary tangle pathology resulting from hyperphosphorylation and aggregation of tau protein [3]. ... Amino acids in the form of proteins are a large part of the human diet.

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The protein behind it all

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Https://www.rcsb.org/pdb/explore/jmol.do?structureId=2OTK&opt=3&jmolMode=HT...

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BIOENGINEERING

THE ENGINEER OF OUR BODY’S PROTEINS

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HOW RESEARCHERS USE ALZHEIMER’S

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PRACTICAL APPLICATIONS OF ALZHEIMER’S

When an organism has been diagnosed (mostly monkeys, apes, and mice) researchers monitor their brain and how fast it is dying. By observing the primates brains it helps researchers plan experiments to try to help humans.

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These primates brains are so closely related to our human brains that most drugs tried on monkeys/apes helps researchers know the affects the drugs will have on us. If the drugs didn’t help them then more than likely they won’t help us .

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PROTEIN MISFOLDING

WHAT CAUSES THE PROTEIN MISFOLD OF ALZHEIMER’S

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Research is being done but not one thing has been pinpointed to cause proteins to fold or to unfold. Many want to believe it is in our DNA but that idea has not been proven by reasonable research.

22.

Worldwide almost 30 million suffer from Alzheimer's disease. The brains of people with Alzheimer's contain two types of misfolded proteins -- amyloid plaques and tangles of the protein Tau. Whether these protein abnormalities are a cause of Alzheimer's or a consequence of the disease are unclear. A new paper in PLoS Biology investigates the structure of Tau to better understand its role in healthy cells and in the pathology of Alzheimer's.

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A FEW AFTERWORDS

WHAT MANY PEOPLE THINK OF ALZHEIMER’S AND ITS RESEARCH

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When someone says Alzheimer’s most people think only of a dying brain but that’s not all it all starts with a misfolding of a protein.

25.

Alzheimer’s can affect anyone it doesn’t choose a certain gender, race, or age group.

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The results of Alzheimer’s is death, however researchers have found ways to slow it down but they have NOT found a cure.

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THE VIEWS OF RESEARCH ON THE PRIMATES

Many people do not believe in using the other primates in our family for research.
People think that using animals in research is cruel but some say that since they already have Alzheimer’s in their brain why not observe or test medications on them to see how their brains and bodies react.
The animals used are NOT hurt or harmed in any way... they are taken care of just like a human that has Alzheimer’s is.

28.

“Almost all aspects of life are engineered at the molecular level, and without understanding molecules we can only have a very sketchy understanding of life itself.”
-Francis Crick

29.

WORKS CITED

WHERE I GOT ALL MY KNOWLEDGE]”19”

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Untitled Slide

I hate that when I put a little too much on a page it doesn’t show all in the presention and cuts it off even if I don’t have a title it still shows where one should be.

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Slide Notes

Alzheimerâs Disease

MORE DECKS TO EXPLORE

PRESENTATION OUTLINE

Untitled Slide

BIOPROSPECTING

Organisms Affected

The abnormalities of Alzheimer's disease can be found in primates, ie humans, apes and monkeys, and in certain strains of mice.

How organisms affected by Alzheimer's survive in their environment

Many of the organisms affected by Alzheimer’s disease cannot live independently. The disease causes the organism to forget nearly everything it knows including names of loved ones, times for medicine, or how to take care of themselves.

The First Discovery

Alzheimer's disease is named after Dr. Alois Alzheimer. In 1906, Dr. Alzheimer noticed changes in the brain tissue of a woman who had died of an unusual mental illness. Her symptoms included memory loss, language problems, and unpredictable behavior.

BIOCHEMISTRY

The biochemistry of Alzheimer's disease (AD), one of the most common causes of adult dementia, is not yet very well understood. AD has been identified as a protein misfolding disease due to the accumulation of abnormally folded amyloid beta protein in the brains of Alzheimer's patients.

HYDROPHOBIC?/HYDROPHILIC?

THE NEGATIVE “TUDE” OF ALZHEIMER’S

THE GOOD GUY AMINO ACIDS

The protein behind it all

Https://www.rcsb.org/pdb/explore/jmol.do?structureId=2OTK&opt=3&jmolMode=HT...

BIOENGINEERING

HOW RESEARCHERS USE ALZHEIMER’S

PRACTICAL APPLICATIONS OF ALZHEIMER’S

These primates brains are so closely related to our human brains that most drugs tried on monkeys/apes helps researchers know the affects the drugs will have on us. If the drugs didn’t help them then more than likely they won’t help us .

PROTEIN MISFOLDING

Research is being done but not one thing has been pinpointed to cause proteins to fold or to unfold. Many want to believe it is in our DNA but that idea has not been proven by reasonable research.

A FEW AFTERWORDS

When someone says Alzheimer’s most people think only of a dying brain but that’s not all it all starts with a misfolding of a protein.

Alzheimer’s can affect anyone it doesn’t choose a certain gender, race, or age group.

The results of Alzheimer’s is death, however researchers have found ways to slow it down but they have NOT found a cure.

THE VIEWS OF RESEARCH ON THE PRIMATES

“Almost all aspects of life are engineered at the molecular level, and without understanding molecules we can only have a very sketchy understanding of life itself.”-Francis Crick

WORKS CITED

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Alyssa Landrum

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Alzheimerâs Disease

“Almost all aspects of life are engineered at the molecular level, and without understanding molecules we can only have a very sketchy understanding of life itself.”
-Francis Crick