Harvard was formed in 1636 by vote of the Great and General Court of the Massachusetts Bay Colony. It was initially called "New College" or "the college at New Towne". In 1638, the college became home for North America's first known printing press, carried by the ship John of London. In 1639, the college was renamed Harvard College after deceased clergyman John Harvard, who was an alumnus of the University of Cambridge. He had left the school £779 and his library of some 400 books.
In the early years the College trained many Puritan ministers. The college offered a classic academic course based on the English university model—many leaders in the colony had attended the University of Cambridge—but one consistent with the prevailing Puritan philosophy. The college was never affiliated with any particular denomination, but many of its earliest graduates went on to become clergymen in Congregational and Unitarian churches throughout New England. An early brochure, published in 1643, described the founding of the college as a response to the desire "to advance learning and perpetuate it to posterity, dreading to leave an illiterate ministry to the churches"
The leading Boston divine Increase Mather served as president from 1685 to 1701. In 1708, John Leverett became the first president who was not also a clergyman, which marked a turning of the college toward intellectual independence from Puritanism.
During the 20th century, Harvard's international reputation grew as a burgeoning endowment and prominent professors expanded the university's scope. Rapid enrollment growth continued as new graduate schools were begun and the undergraduate College expanded. Radcliffe College, established in 1879 as sister school of Harvard College, became one of the most prominent schools for women in the United States. Harvard became a founding member of the Association of American Universities in 1900.