After Caccini's first husband (Giovanni Battista Signorini, with whom she had one daughter, Margherita, in 1622) died in December 1626, she quickly arranged to marry again in October 1627, this time to a melophile nobleman in Lucca, Tommaso Raffaelli.
Francesca Caccini wrote some or all of the music for at least sixteen staged works. All but La liberazione di Ruggiero and some excerpts from La Tancia and Il passatempo published in the 1618 collection are believed lost.