You need to start by finding your core message. It's the most important thing you want your audience to remember or do as a result of your talk, and should be what you build your presentation around.
For example, if your talk is on stroke perhaps your core message is "identifying stroke mimics before giving tPA is an essential clinical skill".
Here is a resource to learn more about crafting your core message:
http://www.speakingaboutpresenting.com/content/memorable-key-message-10-min...