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Harriet Beecher Stowe’s significance was that she provoked anti-slavery forces and changed, peoples minds on human slavery by writing, her famous novel, uncle Tom’s Cabin. This novel ended the institution of slavery. Her book shared ideas about the injustice of slavery, pushing back against the main culture beliefs about the physical and emotional capacity of African Americans. Mrs. Stowe’s novel encouraged others to speak out, furthering the relations between northern and southern states, and advancing the nations march towards the Civil War.