Chronic Pancreatitis
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PRESENTATION OUTLINE
Irreversible damage to the pancreas
Photo by Micaela Parente
Stellate cell activation
Cytokine expression
Production of ECM proteins
Inflammation
Collagen deposition
Photo by NIAID
TOXIC-METABOLIC
- Alcohol
- Tobacco smoking
- Hypercalcaemia
- Chronic renal failure
- Medications—phenacetin abuse
- Toxins—organotin compounds
Photo by Fabian Fauth
GENETIC
- Cationic trypsinogen (PRSS1)
- CFTR gene
- Calcium sensing receptor
- Chymotrypsin C gene
- Pancreatic secretory trypsin inhibitor gene (SPINK1)
Photo by M Pinarci
AUTOIMMUNE
- Type 1autoimmune chronic pancreatitis
- IgG4 systemic
- Type 2 autoimmune pancreatitis
Photo by AJC1
RECURRENT AND SEVERE ACUTE PANCREATITIS
- Postnecrotic
- Recurrent acute pancreatitis
- Vascular diseases/ischaemia
- Radiation induced
Photo by Thomas Hawk
OBSTRUCTIVE
- Pancreas divisum
- Duct obstruction
- Preampullary duodenal wall cysts
- Post-traumatic pancreatic duct scars
Photo by Kurayba
