Necrotizing myopathy

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• Characterized by a predominant muscle fibre necrosis and regeneration
• With little or no associated inflammation
• This histological pattern is observed in acquired myopathy
• But also in muscular dystrophy

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• Acquired NM can be secondary to drugs or toxics
• If it's not, then autoimmune systems have to be suspected
• Necrotizing autoimmune myopathy is recognized as a subgroup of idiopathic inflammatory myopathies
• Which is different from other myositides.

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• Generally, patients present a rapidly progressive and severe symmetrical proximal weakness
• high serum creatine kinase level
• Can be associated in some patients with cardiac involvement
• On the other hand, a slower progression may sometimes be observed
• Could lead to erroneous diagnosis of muscular dystrophy

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• Necrotizing auto-immune myopathy can also be described in association with connective tissue diseases such as lupus or sclerodermia
• cancer association may be observed
• Many different types of cancer have been reported in association with this disorder

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• Necrotizing autoimmune myopathies are now considered as a new entity
• Treatable by immunosuppressants
• Some patients who are unresponsive to corticosteroids my use immunosuppressive therapy

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• Shoulders and thighs are frequently affected
• Some patients who are unresponsive to corticosteroids my use immunosuppressive therapy

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• Weakness can also affect the respiratory muscles making it hard to breathe
• And it also affects the muscles of the throat and neck
• Making it hard to hold up your head and swallow
• Necrotizing Myopathy can worsen the prognosis of people with cancer
• Early diagnosis and treatment is important

DEFINITIONS

• Necrosis: death of a circumscribed portion of animal or plant tissue.
• Histological: the structure, especially the microscopic structure, of organic tissues.
• Myopathy: any abnormality or disease of muscle tissue.
• Dystrophy: Medicine/Medical. faulty or inadequate nutrition or development. Pathology. any of a number of disorders characterized by weakening, degeneration, or abnormal development of muscle.
• Myositides: inflammation or degeneration of muscle tissue