PARKNISON'S DISEASE

WHAT IS IT?

• Brain disease
• Movements
• Mind
• Old age

WHY DOES IT HAPPEN?

• Idiopathic (unknown cause)
• Environmental factors
• Genetic Mutation
• Combination of both

WHAT IS HAPPENING

• Death of nerve cells
• Dopamine isn't produced
• Result is Parkinson's

SYMPTOMS

• Tremors
• Loss of strength (Slower)
• Rigidty
• Dementia (higher risk)
• Sleep, Balance, Speech, etc.

CALCIUM

• High calcium levels
• Cell death in the Substantia nigra
• Oxidative stress
• Cav 1,3

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Cell Communication

• Defects in synaptic transmission
• Dopamine should cross synapse
• In Parkinson's, not enough cross

TREATMENT

• No cure
• Calcium channel blockers
• Relieve and slow progression

CONCLUSION

• Death of dopamine producing cells
• High calcium levels
• Low dopamine levels
• Parkinson's symptoms start
• Worse with time, but doesnt kill