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Poisoning

Published on Jan 11, 2016

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PRESENTATION OUTLINE

Poisoning

Ian mitchell, md, FRCP
Photo by Leo Reynolds

Overdose vs Poisoning

Photo by DES Daughter

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Call the Poison Center. It is very helpful for patient management, but also important in terms of collecting statistics.

Objective: Discuss preventing and treating overdoses with parents.

Objective: Clarify consequences of overdose by calling Poison Center
Photo by A.Currell

Toxic Granny

What makes pills attractive to kids?

Bright colors - laundry pods now significant cause of exposures.

Taste - unlikely to ever see a zopiclone overdose in a child

Look like candy - vitamins, iron tablets.
Photo by Bsivad

Multiple ingestions

Objective: Think about multiple substances in overdose.

Special concerns: alcohol, ASA, acetaminophen.

Screening ECG - looking for ?

Timing

Are all overdoses equally time sensitive?
Metabolized toxins
Methadone
Acetaminophen level timing

Objective: Take a good history regarding the timing and nature of the overdose.

What other questions are important?

What else could the patient have access to? (ie hand sanitizer)
Photo by mags504

Toxidromes

Photo by rvacapinta

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Sympathomimetic, much?

Photo by El Cabron

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“FARM”: Fever, Altered mental status, Rigidity, Myoclonus


The clinical picture of serotonin toxicity can best be described as a triad of cognitive, autonomic and somatic effects. In mild cases, the cognitive effects may simply consist of abnormal mood, such as hypomania, but in severe cases, mental status is altered and patients may experience severe agitation and hallucinations. The autonomic effects consist of diaphoresis, hypertension, hyperthermia, tachycardia and diarrhea. In severe cases, marked hyperthermia can give rise to additional complications, such as rhabdomyolysis, seizures, metabolic acidosis and disseminated intravascular coagulation. Finally, the somatic effects are essential for the diagnosis; these are myoclonus, tremor and hyperreflexia with clonus.

OTHER MEDS

  • Phenytoin
  • Lithium
  • Barbiturates
Photo by Myriam Zilles

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Objective: Assess, manage and reassess ABCs

Don't focus on antidotes and decontamination while ignoring the effects of the poisoning

Benzos for seizures. Or phenobarb. Avoid dilantin

Decontamination

Photo by euthman

Charcoal

Needs to be given in a 10:1 ratio

Massive surface area.

Disadvantages: messy, forms intestinal briquettes, aspiration, doesn't affect small molecules.
Photo by ToastyKen

Bowel Irrigation

PEG at 2 L/hour until effluent clear

For drugs poorly absorbed by charcoal, very toxic ingestions, body packers.

Antidotes

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Photo by intropin

Naloxone Ninja Moves

Lower dose

Reverse hypercarbia before giving naloxone.

Nebulized naloxone

2 mg in 2cc NS
Photo by wuestenigel

Oral Naloxone for Constipation

Photo by Abulic Monkey

Acetaminophen/NAC

Common, toxic, available in large quantities.

Depends on metabolism for toxicity

Alcoholics at high risk for toxicity

Immodium

Photo by wisefly

From Our Prescription Pad

  • quetiapine
  • opiates, tramadol
  • benztropine
  • baclofen
  • gabapentin, pregabalin
  • bupropion
Photo by frankieleon

tramadont

  • Erratic metabolism
  • Seizures
  • Serotonin syndrome
  • Hypoglycemia
  • Massive worldwide addiction
  • Sale funds terrorism
Photo by frankieleon

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