PRADER-WILLI SYNDROME

Prader-Willi Syndrome is a congenital condition (present at birth) and is believed to be caused by an abnormality in the genes that occurs. It's a rare genetic disorder in which seven genes on chromosome 15 are deleted or unexpressed.

SYMPTOMS

• Are usually small at birth but when developing into an adult they get more obese.
• Seem floppy and feel like a rag doll when held
• Show changes in the face, such as almond shaped eyes, and a small downturned mouth
• Intellectual disability
• Delayed motor development

The Diagnosis
The diagnosis is confirmed by a drug test. The method of testing is a "methylation analysis", which detects 99% of cases including all of the major genetic subtypes of PWS.

Causes of PWS
PWS is caused by the loss of genes in a specific region of chromosome 15. Prader-Willi syndrome occurs when the region of the paternal chromosome 15 containing these genes is missing.

Complications of PWS

• Type 2 Diabetes
• Heart Disease and Stroke
• Sleep Apnea
• Liver Disease
• Swollen Joint Pain

TREATMENT

• Improve physical health and agility
• Improve height
• Increase lean muscle mass and decrease body fat
• Increase bone mineral density
• Increase stamina

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