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Protein Folding & Impact Of Mutations

Published on Nov 24, 2015

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PRESENTATION OUTLINE

1.

PROTEIN FOLDING

THE PROCESS BY WHICH A PROTEIN STRUCTURE ASSUMES ITS FUNCTIONAL SHAPE OR CONFORMATION.
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2.

WHEN AMINO ACIDS ARE ASSEMBLED IN A LINE TO MAKE A PROTEIN, THEY DO NOT STAY IN AN EVEN, STRAIGHT LINE.

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3.

PRIMARY LEVEL

THE ORDER OF AMINO ACIDS IS DETERMINED BY MRNA AND DNA
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4.

SECONDARY LEVEL

The shape created by these amino acids
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5.

TERTIARY LEVEL

The overall shape created by the entire string of amino acids
6.

QUATERNARY LEVEL

THE FINAL LEVEL, IS THE MIXTURE OF PROTEINS (SUBUNITS) TO CREATE A FUNCTIONAL PROTEIN
7.

ANY CHANGE TO THE DNA IS CALLED A MUTATION

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8.

MUTATIONS ARE RESPONSIBLE FOR GENETIC DISEASES SUCH AS CANCER AND INHERITABLE DISORDERS.

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9.

A mutation may cause a dramatic change to the codons (groups of 3 bases)

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10.

TWO SHAPES OF PROTEINS

ALPHA HELIX AND A BETA SHEET

Hailey Winkler