Protein Folding
Published on Nov 29, 2015
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PRESENTATION OUTLINE
PROTEIN FOLDING
ALEX HYNES
PROCESS BY WHICH A PROTEIN STRUCTURE ASSUMES ITS FUNCTIONAL
SHAPE OR CONFORMATION
EACH PROTEIN EXISTS AS AN UNFOLDED POLYPETIDE WHEN TRANSLATED
FROM A SEQUENCE OF MRNA TO A LINEAR CHAIN OF ANIMO ACIDS
AMINO ACIDS INTERACT WITH EACH OTHER TO PRODUCE A FOLDED
PROTEIN, KNOWN AS THE NATIVE STATE
THE CORRECT STRUCTURE IS ESSENTIAL TO FUNCTION
ALTHOUGH SOME PARTS OF FUNCTIONAL PROTEINS MAY REMAIN UNFOLDED
FAILURE TO FOLD INTO NATIVE STRUCTURE PRODUCES INACTIVE
PROTEINS THAT ARE USUALLY TOXIC
SEVERAL NEURODEGENATIVE AND OTHER DISEASES ARE BELIEVED TO
RESULT FROM THE ACCUMULATION OF AMYLOID FIBRILS FORMED BY MISFOLDED PROTEINS
MANY ALLERGIES ARE CAUSED BY THE FOLDING OF PROTEINS, FOR THE
IMMUNE SYSTEM DOES NOT PRODUCE ANTIBODIES FOR CERTAIN PROTEIN STRUCTURES
SEVERAL EXTERNAL FACTORS SUCH AS TEMPERATURE, EXTERNAL FIELDS,
MOLECULAR CROWDING, & LIMITATION OF SPACE HAVE AN INFLUENCE ON THE FOLDING
PROTEIN FOLDING IS A FINING TUNED PROCESS.
HYDROGEN BONDING BETWEEN DIFFERENT ATOMS PROVIDES THE FORCE REQUIRED
