Pycnogenol

History

• Maritime Indians developed a variety of herbal drugs 
• Nature provides cures for all illnesses; trial and error  
• First reported Indian cure for Jaques Cartier and crew 1535
• Men dying from scurvy 
• Instant cure; decoction of bark and leaves 

Overview

• Pycnogenol® French maritime pine bark extract
• Les Landes de Gascogne forest in southwest France
• Unspoiled and natural, no pesticides, no herbicides.
• Not subject to seasonal variations
• Pycnogenol® extraction process is patented

Company

• Horphag Research in Geneva, Switzerland 
• 40 years of research for safety of Pycnogenol® 
• Benefits to Human health 
• Guarantees its constant high quality.
• 100+ published clinical studies;  300+ scientific publications

Composition

• Procyanidins and bioflavonoids
•  Phenolic acids and other organic acids  

chemistry

• Proanthocynaidins are biopolymers
• Chain lengths from 2-12 mono metric units
• Phenolic acids are derivates of benzoic acid
• Found in free form and as glucosides & free glucose
• Inorganic substances: Ca, K, Fe, Mn, Zn, Cu

Safety

• "Gold Standard Ingredient" 
• 40 years extensive research
• GRAS, GMP, Kosher certified 
• No known side effects; non-toxic 
• 30+ best selling drug 

Production

• Cleaned, selected and crushed pieces
• Extraction steps involving water and ethanol as eluents 
• Purified aqueous extract is spray-dried
• very fine, brownish-colored, water soluble powder 
• Factory located in heart of forest

Primary Uses

• Powerful antioxidant
• Natural anti-inflammatory
• Generate collagen and hyaluronic acid
• Production of endothelial nitric oxide

Other Main Uses

• ADHD
• Asthma
• Cholesterol/dyslipidemia
• Chronic Venous Insuffficiency
• Diabetes 

Other main uses cont.

• Dysmenorrhea
• Endometriosis
• Erectile Dysfunction
• Hypertension
• Melasma

Other uses cont.

• Muscle Cramps
• Osteoarthritis 
• Perimenopause 
• Platelet Function
• Retinopathy 

Antioxidant

• More powerful than vitamins C and E (Nelson and Packer 1999)
• Recycles vitamins C and E; re-used and prolonging life span
• Increases production of own natural defenses (Wei 1997)
• Free Radical Defense
• Slow the aging process and counteract problems associated with it

Anti-inflamatory

• Inhibits generation of COX-2 and 5-LOX enzymes
• Pro-infalmmatory enzymes 
• Decrease pain and reduce inflammatory conditions
• Dr. Canali Study 
• Asthma, allergies, arthritis, cancer, IBD, Parkinsons 

Collagen & hyaluronic acid

• High amounts of collagen remain tightly bound 
• Protects collagen from enzymatic degradation 
• Prevents UV damage and photo-ageing 
• inhibits melanogenesis and lowers pigmentation intensity
• Increases skin elasticity in humans 

endothelial nitric oxide

• Normalization of blood pressure and platelet function (Hosseini 2001)
• Improvement of blood lipids as well as blood sugar values (Devaraj 2002)
• Strengthens capillary walls (Rohdewald 2002) 
• Hypertension, atherosclerosis, diabetes, cardiovascular disease, & age
• Blood vessel constriction;impairs blood flow; increased "sticky" platelets

Current research

• Sports (Wang et al., 1999; Kohama 2004) 
• Tinnitus (Chieti-Pescara University; Panminerva Medica)
• Diabetes (Liu et al., 2004)
• Congnitive Function (Dementia/ADHD) 

Untitled Slide

Untitled Slide

Untitled Slide

Video

conclusion