"Pyometra is often the result of hormonal changes in the reproductive tract. Following oestrus ("heat") in the dog, progesterone levels remain elevated for eight to ten weeks and thicken the lining of the uterus in preparation for pregnancy. If pregnancy does not occur for several oestrus cycles, the lining continues to increase in thickness until cysts form within it. The thickened, cystic lining secretes fluids that create an ideal environment in which bacteria can grow. Additionally, high progesterone levels inhibit the ability of the muscles in the wall of the uterus to contract" ("Pyometra In Dogs").