Scleroderma is a autoimmune, rheumatic and chronic disease that affect the body by hardening connective tissue (connective tissue is widespread it add strength to organs and other parts of the body) connective tissue is made of many proteins. Among them is collagen of the skin
No one really knows enough about scleroderma to know whether there is a way to prevent but Depending on the organs involved, medication may effectively slow or stop the disease's progression.