The CONE SNAIL
Published on Nov 18, 2015
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PRESENTATION OUTLINE
The CONE SNAIL
Shelby Oakes
The Marine Cone SNail
- Located in most warm water climates.
- 500+ Species
- Hundreds of toxins
- Piscivores, Molluscivors, Vermivores
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Conus Geographus
The Geography Snail
Deadliest Cone
- Piscivore
- Venom is a complex of hundreds of toxins
- 30+ human deaths.
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The HArpoon
Cone Snails use harpoon guns to take down prey
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Geographus Venom
Cell Signaling Pathways
- 12-30 amino acids made up of peptides.
- Peptides packed with disulfide bonds (Ligand)
- Attaches to prey's ion channels.
Conotoxin
- Conotoxin Protein binds to active site
- Sodium channels stay open
- Potassium channels close
- Continuous action potential causes constant contraction.
w-conotoxin (GViA)
- Blocks Calcium channels.
- Interrupts voltage mediated calcium
- Interferes with victims pain-signaling.
