Toxicology by Chris Soliz

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Slide Notes

The discipline of Toxicology has a long history
- published works as early as 1198 (Poisons and Their Antidotes by Maimonides)

Important to society because of contributions to the understanding of chemicals, drugs, and additives we are exposed to every day.

Every aspect of our life is touched
- work & home

Toxicology

A brief introduction to the disciplines of Toxicology.

PRESENTATION OUTLINE

TOXICOLOGY

MANY SUBSTANCES; mANY DISCIPLINES

The discipline of Toxicology has a long history
- published works as early as 1198 (Poisons and Their Antidotes by Maimonides)

Important to society because of contributions to the understanding of chemicals, drugs, and additives we are exposed to every day.

Every aspect of our life is touched
- work & home

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The study of the nature and mechanisms underlying toxic effects exerted by substances on living organisms and other biological systems.

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ORGANIZATION

Scope
Sub disciplines
Foundational Basis
Application

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SCOPE

Medicine
Food industry
Agriculture
Chemical
Metallurgical

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SUB DISCIPLINES

Analytical
Clinical
Forensic
Occupational
Environmental
Regulatory

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FOUNDATIONAL BASIS

CONVENTIONAL & MECHANISTIC TOXICOLOGY

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RESULT: RISK MANAGEMENT

Risk analysis
Codifies scope and sub-disciplines
Basis for public education

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RESULTS

US FDA: 100-fold margin
OSHA: Occupational Safety and Health Act
Consumer Product safety act
Safe drinking water act

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CONSIDERATIONS

Thalidomide: common sedative
Lead poisoning

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FUTURE

TOXICITY TESTING IN THE 21ST CENTURY

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References
Kacew, S., & Lee, B. (2013). Lu's basic toxicology: Fundamentals, target organs, and risk assessment (6th ed.). London, United Kingdom: Informa Healthcare.

Chris Soliz