Trimethylaminuria

STRUCTURE AND FUNCTION OF DNA

• "Genetic information is carried in the linear sequence of nucleotides in DNA. Each molecule of DNA is a double helix formed from two complementary strands of nucleotides held together by hydrogen bonds between G-C and A-T base pairs."

SYMPTOMS

• Nasty odor - usually smells like fish, eggs, or urine
• Usually worse when stressed
• Can cause social and psychological problems
• Liver failure
• Increased blood pressure
• Severe depression

Trimethylaminuria is inherited, and is received when both parents have a missing FMO3 gene. Valine is turned into Leucine

DNA: ATG CAC TTC
Original Strand RNA Codon:
UAC GUG AAG
Tyrosine Valine Lysine

Mutated DNA: ATG TAC TTC
RNA Sequence:

UAG AUG AAG
Tyrosine Leucine Lysine

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TREATMENT

• Avoid foods containing trimethylamine
• Low dose of antibiotics can lesson the smell
• Screening at birth is available

Babies should be screened at birth for this disease so that they can start treatment early.

GENETIC PROFILING

• Genetic profiling for this desease won't effect any job opportunities or other life things.